Does Denamarin affect appetite?

Occasionally, it seems to cause a decreased appetite in some dogs, but this is very rare. If possible, it is best given on an empty stomach. Skorupski, K.A., et al. Prospective Randomized Clinical Trial Assessing the Efficacy of Denamarin for Prevention of CCNU-Induced Hepatopathy in Tumor-Bearing Dogs.
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What are the side-effects of Denamarin?

Denamarin® Advanced Tablets have no known serious side-effects. If your pet is using this medication for the first time please watch for any allergic reactions that might occur, if your pet develops a rash, etc call your veterinarian immediately. If you notice anything unusual, contact your veterinarian.
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Do elevated liver enzymes increase appetite in dogs?

In a pet with increased appetite, the serum biochemistry profile might show: Mild elevation of liver enzymes. These changes are associated with Cushing's disease, diabetes mellitus, hyperthyroidism in cats, and the use of corticosteroid-containing medications in dogs.
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Should Denamarin be given morning or night?

Where possible we recommend an overnight fast to ensure the stomach is empty before administering the tablet, thereby allowing the best absorption of the active ingredients. However, when an overnight fast is not possible please allow a minimum of 2 hours (ideally longer) after feeding before administering the tablets.
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How long should a dog stay on Denamarin?

How long should my dog take Denamarin? Your vet will be able to advise you on what is best for your pet. Some conditions, such as acute liver toxicity (poisoning) may only need a few weeks of treatment, whereas longer-term diseases may require ongoing medication.
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5 of the DEADLIEST Veterinary Medications for Pets

Does Denamarin make dogs lose appetite?

Therefore, we evaluate each patient individually to determine if the potential benefits of Denamarin outweigh the potential risks. This supplement seems to be very well tolerated. Occasionally, it seems to cause a decreased appetite in some dogs, but this is very rare. If possible, it is best given on an empty stomach.
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What happens if I give my dog Denamarin with food?

While you should always give your pet the medication on an empty stomach, this also has shown to have no major adverse reactions. If you happen to forget and your dog does have foods prior to taking the medicine, it will just lower the effectiveness.
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Does Denamarin help dogs' kidneys?

Commercially available supplements for dogs with kidney disease are also an option. Look for ones that include vitamin E, zinc, S-Adenosylmethionine (SAM-e), milk thistle, and ursodiol. Commercial companies produce Denamarin and Denosyl (labeled as kidney mixes containing SAM-e and Silybin) as supplements for pets.
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Does Denamarin increase urination?

Denamarin is not expected to cause an increase in urination.
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Can a dog have too much Denamarin?

The specific silybin-phosphatidylcholine complex in Denamarin has been evaluated in both acute and chronic use safety studies: an acute toxicity study in dogs using levels greater than 80x the amount in Denamarin revealed no adverse physiologic effects, 38 and a chronic toxicity study in monkeys who received greater ...
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What not to feed a dog with high liver enzymes?

Usually, dogs with liver disease are recommended to avoid:
  • Foods high in copper or salt, such as lamb, duck, pork and offal.
  • Red meats high in protein, such as beef.
  • Dog food containing meat meal, preservatives, artificial ingredients and high sugar.
  • Table scraps and human leftovers.
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Does liver disease in dogs cause hunger?

It's important to talk to your vet if you notice any changes in your furry friend. Detecting liver issues early can really help with treatment and making sure your pup feels better sooner. Increased hunger may be a sign of liver disease in dogs.
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Can high liver enzymes cause loss of appetite?

Jaundice (yellowing of your skin or eyes). Light-colored stools (poop). Loss of appetite. Nausea and vomiting.
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How to know if Denamarin is working?

How will I know if Denamarin is helping my pet? Your vet is likely to recommend follow‑up examinations and blood tests to check on how Denamarin is helping to improve your pet's liver function. At home, watch for improvements in attitude, appetite and activity level.
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Can I give Denamarin every other day?

For Large Dogs

Many pets are maintained long-term on every-other-day or every-third-day administration.
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What is a good substitute for Denamarin?

Denamarin is a combination of an anti oxidant called SAMe, which can be found online and in stores, and marin, the active ingredient in milk thistle. You could try a combination of milk thistle (about 1/4th of the labeled dose for a person) and SAMe (around 225 mg).
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Does Denamarin make dogs sleepy?

Denamarin has no known side-effects. Your veterinarian can evaluate the length of support needed through follow-up examinations, blood work and/or other laboratory work. At home, watch for a response in your pet's attitude, appetite, and activity level.
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What time of day should Denamarin be given?

Denamarin® Advanced should be given orally as directed by your veterinarian. For optimal absorption give on an empty stomach at least one hour before a meal.
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Is Denamarin safe for long term use?

This depends on the current condition of your dog. These tablets are safe for long term use. We recommend consulting a veterinarian for accurate feeding regimes based on your dog's health.
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Can dogs take Denamarin with food?

A: Yes! The packaging says “tablets should be given on an empty stomach; however, if needed they can be administered with a small amount of food or treat.” (The reason I took my Sheltie to the vet in the first place was because he suddenly stopped eating.
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What is the best appetite stimulant for dogs with kidney disease?

Mirtazapine

Mirtazapine is a common drug prescribed to dogs that have a decreased appetite due to conditions that make them feel queasy (such as kidney disease or cancer) or medications (such as chemotherapy). Mirtazapine was initially developed as an antidepressant in humans.
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How to increase appetite in dogs with kidney failure?

Feed your dog small meals, often, rather than giving him one or two large meals in a day. Offer fresh food at each feeding. Make sure your dog always has access to clean, fresh water. Sometimes, dogs that have chronic kidney failure don't feel like eating.
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Can too much Denamarin hurt a dog?

There are two ingredients in Denamarin: SAMe is one, and it is very safe. The drug book lists it as "quite safe". A single double dose is not expected to cause any problems, except for perhaps some diarrhea.
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What happens if a human takes Denamarin?

Most likely nothing will happen after taking the Denamarin. You can read more about S -Adenosylmethionine here.
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What drugs interact with Denamarin?

While no drug interactions have been documented, in theory, Denamarin® Advanced Tablets may have an effect on: Tramadol, dextromethorphan, meperidine, selegiline, fluoxetine, amitriptyline, clomipramine and other antidepressant medications, warfarin, verapamil, diazepam.
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