What drugs interact with Denamarin for dogs?

While no drug interactions have been documented, in theory, Denamarin® Advanced Tablets may have an effect on: Tramadol, dextromethorphan, meperidine, selegiline, fluoxetine, amitriptyline, clomipramine and other antidepressant medications, warfarin, verapamil, diazepam.
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What are the long term side-effects of Denamarin in dogs?

Denamarin has no known side-effects. Your veterinarian can evaluate the length of support needed through follow-up examinations, blood work and/or other laboratory work. At home, watch for a response in your pet's attitude, appetite, and activity level.
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Can my dog take Denamarin with food?

Denamarin tablets should be given on an empty stomach, at least one hour before a meal to maximize absorption of the product. You could give the tablets first thing in the morning after an overnight fast, before breakfast. If you need to, then you can disguise the tablets in a small amount of food.
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Can I give my dog Denamarin and gabapentin at the SAMe time?

Denamarin can be given with gabapentin. Denamarin should be given on an empty stomach.
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Is Denamarin an anti-inflammatory?

Denamarin is a liver-protecting supplement used to reduce inflammation in the liver and subsequently, reduce elevated liver enzymes found on blood work. It also reduces the toxic effects of a chemotherapy drug called CCNU (aka lomustine).
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5 of the DEADLIEST Veterinary Medications for Pets

Can you give Denamarin with other medications?

While no drug interactions have been documented, in theory, Denamarin® Advanced may have an effect on: Tramadol, dextromethorphan, meperidine, selegiline, fluoxetine, amitriptyline, clomipramine and other antidepressant medications, warfarin, verapamil, diazepam.
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What medications should not be taken with milk thistle?

Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes:
  • Allergy drugs. ...
  • Drugs for high cholesterol. ...
  • Anti-anxiety drugs. ...
  • Antiplatelet and anticoagulant drugs (blood thinners). ...
  • Some cancer drugs. ...
  • Drugs broken down by the liver.
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Can I give Denamarin every other day?

For Large Dogs

Many pets are maintained long-term on every-other-day or every-third-day administration.
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Is gabapentin hard on a dog's liver?

Gabapentin should be used with caution in animals with decreased liver or renal function. Be sure to tell your veterinarian about any medications, vitamins, supplements, or herbal therapies that you are giving your pet.
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Can you give a dog too much Denamarin?

You may see a little upset stomach, such as vomiting, in the first 24 hours after ingestion of the medicine. However, it should improve with time and it is unlikely you will even see that. Denamarin is a very safe medication/supplement to give even at high doses like that.
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How long should a dog stay on Denamarin?

How long can my dog stay on denamarin? This depends on the current condition of your dog. These tablets are safe for long term use. We recommend consulting a veterinarian for accurate feeding regimes based on your dog's health.
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Should Denamarin be given at night or morning?

Where possible we recommend an overnight fast to ensure the stomach is empty before administering the tablet, thereby allowing the best absorption of the active ingredients. However, when an overnight fast is not possible please allow a minimum of 2 hours (ideally longer) after feeding before administering the tablets.
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Can dogs have water with Denamarin?

Denamarin® Advanced Tablets should be given orally as directed by your veterinarian. For optimal absorption give on an empty stomach at least one hour before a meal. It is suggested that tablets should be followed immediately with a small amount of water to make sure the tablet passes all the way into the stomach.
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Does Denamarin increase urination?

Denamarin is not expected to cause an increase in urination.
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How long can a dog live with high liver enzymes?

Some dogs have mild liver disease that progresses slowly and remains relatively stable over months, or even years. Other dogs may have a rapid progression of liver failure. And they may only live for weeks, or even days, following their diagnosis.
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What is a good substitute for Denamarin?

Denamarin is a combination of an anti oxidant called SAMe, which can be found online and in stores, and marin, the active ingredient in milk thistle. You could try a combination of milk thistle (about 1/4th of the labeled dose for a person) and SAMe (around 225 mg).
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What medications cause elevated liver enzymes in dogs?

Common Causes of Elevated Liver Tests in Dogs

Drugs, especially steroids and some antiseizure medications like phenobarbital, frequently increase liver test results.
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What dogs should not take gabapentin?

Higher doses may cause more sedation and problems with walking and balance. Careful use of gabapentin is important for dogs with significant liver or kidney disease. Gabapentin's effects may take longer to wear off for them. In addition, avoid use of gabapentin in pregnant and lactating dogs.
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Can gabapentin cause hind leg weakness in dogs?

Gabapentin may cause a condition called ataxia, in which the dog experiences a loss of motor control, coordination, or balance. This could possibly cause hind leg weakness or trouble walking. If you notice your dog struggling to walk while on gabapentin, contact the vet for assistance.
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What drugs interact with Denamarin?

While no drug interactions have been documented, in theory, Denamarin® Advanced Tablets may have an effect on: Tramadol, dextromethorphan, meperidine, selegiline, fluoxetine, amitriptyline, clomipramine and other antidepressant medications, warfarin, verapamil, diazepam.
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Can you break up Denamarin?

Denamarin tablets are enteric-coated to protect them from being oxidised. They must therefore be fed whole (do not split or crumble the tablets). Tablets should be given on an empty stomach at least one hour before a meal for optimum absorption (an overnight fast is preferred).
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What if I forgot to give my dog Denamarin?

Speak with your veterinarian if you forget to give a dose of Denamarin® or milk thistle/SAMe. Generally, they may recommend that you give it when you remember, or, if it is almost time for your next dose, to skip the missed dose and resume your normal dosing schedule.
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What are the disadvantages of taking milk thistle?

Adverse effects associated with oral ingestion of milk thistle include:
  • Gastrointestinal problems (e.g., nausea, diarrhea, dyspepsia, flatulence, abdominal bloating, abdominal fullness or pain, anorexia, and changes in bowel habits).
  • Headache.
  • Skin reactions (pruritus, rash, urticaria, and eczema).
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Is milk thistle bad for kidneys?

Silymarin has been extensively studied for its therapeutic benefits. Several studies show that milk thistle benefits liver and kidney diseases because of the flavonolignans. Milk thistle is an effective treatment. (1) This article will discuss five reasons milk thistle is nephroprotective and hepatoprotective.
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Can milk thistle cause weight gain?

Milk thistle and silymarin are generally well tolerated in adults with only mild side effects such as diarrhea, headache, and skin reactions. Mothers taking milk thistle to increase milk supply reported weight gain, nausea, dry mouth and irritability occasionally.
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